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They may indicate a patient's predisposition to melanoma, particularly if there is a family history of melanoma (atypical mole or dysplastic naevus syndrome)

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Benefits: Always using fresh peptides No worry about degradation Can adjust doses without wasting partially-used vials Trade-off: Slightly more frequent mixing (minor inconvenience for better quality)

Inflammatory mediators can induce production of prostaglandin E 2 (PGE 2 ) and NO, which in turn have the capacity to promote maturation and increase transport of melanosomes, to upregulate the expression of the tyrosinase gene, and to increase the complexity of the network of melanocytic dendrites

J Invest Dermatol 127(1):179182 Kinsler VA, Thomas AC, Ishida M, Bulstrode NW, Loughlin S, Hing S et al (2013) Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS

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