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There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]

Research published in Biochemical Pharmacology demonstrated that treating cells with 5-Amino-1MQ effectively blocks this leak. It inhibits NNMT, forcing Nicotinamide back into the salvage pathway

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10.1111/j.0954-6820.1968.tb02452.x

in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )