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Such inflammatory molecules induce cell apoptosis, senescence and autophagy and upregulate the synthesis of MMPs (1, 3, 7, 9 and 13) and ADAMTS (1, 4, 5, 9 and 15) through NPCs, thus leading to ECMs catabolism (Risbud and Shapiro, 2014)

A grande maioria dos dados provm de estudos in vivo realizados em modelos murinos e de rato, bem como de experimentos in vitro em culturas celulares