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The activity of these enzymes requires both a reducing agent (nicotinamide adenine dinucleotide phosphate [ NADPH ]) and molecular oxygen

Nevertheless, situations unhealthy for sensitive groups were observed in all station categories and punctually (with low distribution values), unhealthy, very unhealthy, and hazardous states

More recently, it was shown that initial electron leakage and superoxide formation from complex III occur mainly towards the mitochondrial intermembrane space, leading to a mild oxidant stress in the cytosol and activation of a MAP kinase cascade with phosphorylation of c-Jun N-terminal kinase (hereinafter referred to as pJNK)

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