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A study has revealed the mechanism of CRS in CAR-T therapy, where CAR-T recognizes target cells and releases perforin and granzyme B, activating the caspase3-GSDME pathway and leading to cell pyroptosis and CRS

Therefore, both WGS metagenomic analysis and traditional marker-based metagenomics using next-generation sequencing provide culture-independent approaches to comprehensively characterize the human gut microbiome and environmental microbial communities

In the last decade or more, the global prevalence of depression has continued to rise[1,7], with depression accounting for approximately 12% of hospital admissions, 50% of mental health consultations, and 4% of suicides[6,8,9]

Permanent damage is rare

In early 2024, he joined our Firefighter Detoxification Pilot Program