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A critical review of bottom-up proteomics: the good, the bad, and the future of this field

HIF-1 is constitutively active in egl-9(sa307) mutants, which we use here in an integrated genomic, transcriptomic, and metabolomic approach to obtain a holistic and functional description of HIF activation in an intact animal

Sfrp5pepD disrupts the Wnt/-catenin signaling pathway by inhibiting the interaction between Axin-1 and -catenin, affecting the interaction between MITF and -catenin

10.3390/ijms252212013 202

A gastroenterologist advised me to take a multivitamin with iron

Targeting biosensors to different tissues and compartments like this may sometimes require some sensor re-engineering, but it is an approach that is already yielding great new insights into signalling, revealing the spatial specificity of responses