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Freezing reconstituted peptide solutions can cause ice crystals to form that damage the protein structure

HUBERMAN: Why something is doing what it's doing or how it got there

doi: 10.3390/ijms20236008 78 IratoPSantovitoG

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Nonetheless, many clinical investigations are limited by short follow-up durations, small sample sizes, heterogeneous formulations, and reliance on surrogate endpoints, such as variations in bacterial diversity or inflammatory markers, rather than definitive clinical outcomes, thereby limiting the robustness of current conclusions (2, 4)