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Acknowledgements The authors are highly thankful to the Institute of Human Genetics, the University of Jammu, and the Department of Human Genetics (Sri Pratap College, Srinagar, Cluster University Srinagar) for the support in the present study

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Because many of these approaches act systemically and influence multiple stress-response pathways simultaneously, their beneficial effects cannot be interpreted as selective proof that a PAC-specific increase in mitophagy is itself sufficient or universally desirable