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Future challenges to overcome in the development of NRF2 activators as disease modifying treatments include the establishment of compounds with good pharmacokinetic and pharmacodynamic profiles that ensure sustained, brain wide NRF2 activation

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of the Addendum to this proposed rule, we address the proposed update factors for determining the rate-of-increase limits for cost reporting periods beginning in FY 2024 for certain hospitals excluded from the IPPS

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