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Notably, imipramine, by activating the FAM3A-ATP-P2 receptor-CaM-FOXA2-CPT2 pathway, decreases lipid accumulation in hepatocytes, suggesting its potential as a beneficial antidepressant for individuals with concurrent metabolic disorders (290)

4: Heat denaturation of proteins Aqueous solutions of the proteins (RuBisCO and alkaline phosphatase) and peptide (glutathione) were denatured by heat treatment, which has been used in many previous studies as summarized in Supplementary Table 3

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