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In contrast, GDNF mimetics and blood-brain barrier-penetrating CDNF peptides offer the advantages of both targeting and delivery efficiency, with preliminary preclinical or clinical data accumulated, providing a more translationally promising solution to the delivery challenges of NTFs-based therapies

Soh J, Kawauchi A, Kanemitsu N, Naya Y, Ochiai A, Naitoh Y, et al

Challenges of modeling intrinsic bacterial defenses against PMN-derived ROS It is important to note that the chemistry of oxidants in the neutrophil phagosome is far different from that of the cell's surroundings or that of dilute solutions to which oxidants have been added

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YdpA mutant, which had lower levels of BSH and higher levels of BSSB, had reduced survival in human neutrophils [82]

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