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Furthermore, phosphorothioate linkages, where sulfur atoms replace non-bridging oxygen in the phosphate backbone, significantly improve the stability and bioavailability of RNA molecules

Jaeken J, Detheux M, Van Maldergem L, Foulon M, Carchon H, Van Schaftingen E (1996) 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis

The daily dose will depend, according to the judgement of the primary care physician, on the patient's weight, age and condition

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