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258,259 Under stress conditions, Trx is released into the extracellular space where it exerts a cytoprotective effect and cytokine-like activities

In autoimmune conditions, curcumin (1025 M) ameliorates disease severity by suppressing pathogenic Th1/Th17 responses while enhancing the activity of regulatory T cells (Tregs) ( + T-cell function and inactivating the AKT/mTORC1/STAT3/PD-L1 axis ( + T-cell differentiation into CD4 + CD25+FOXP3+ Tregs (Figure 2)

This helps researchers assess the compound's effects more clearly and observe any lasting changes after administration ceases

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National Academies Press (US)