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Metastasis, the spread of cancer cells from the primary tumor to distant sites, is a hallmark of cancer and a major cause of cancer-related mortality [117]

Of these, 42(13%) were exposed to semaglutide or tirzepatide while 324(88%) had no such exposure

The enrichment of some important stealthy proteins such as apolipoprotein A1 and clusterin occurred at even a low concentration of surface PEGylation, demonstrating how the use of PEG, itself, could result in the presence of important proteins that could improve NP pharmacokinetics