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As further consideration of translation of this therapeutic to the clinic, cochlear synaptopathy is implicated as a potential contributor to human tinnitus, although the published evidence is emerging and, so far, is largely indirect 11,60

Sugiya, (2012), Oxidative Stress Environmental Induction and Dietary Antioxidants, Edited by Volodymyr I

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This effect is achieved by terminating the chain reactions initiated by free radical intermediates, as these reagents undergo oxidation themselves and prevent further oxidation reactions

Not only is dithionite a reducing agent, but the strong affinity of the dithionite ion for bivalent and trivalent metal cations (M2+, M3+) allows it to enhance the solubility of iron, making it a chelating agent