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Animal Model:Valproic acid treated young mice [6] Dosage:30 mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms

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The metabolic pathway of TMAO involves multi-organ coordination: dietary choline, carnitine, and other quaternary ammonium-containing compounds are metabolized by gut microbiota to produce trimethylamine (TMA), which is subsequently oxidized to TMAO by hepatic flavin-containing monooxygenases (FMOs) and primarily cleared by the kidneys (170)

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Correia and Vale, 2024)

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