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Age-dependent neurohormonal factors promote increased cardiac fibroblast proliferation and their transition to an intermediate proto-myofibroblast and finally to a myofibroblast state, characterized by alpha-smooth muscle actin (SMA) expression [Figure 6] [135]

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How Scleroderma is Diagnosed Scleroderma can be difficult to diagnose because it can manifest in many forms and impact many areas of the body

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