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An FEV1/FVC ratio less than 0.7 is the gold standard for COPD diagnosis but cannot differentiate between different COPD subtypes

The evaluation of these metabolites and ratios uncovered biologically plausible biomarkers that expand upon the biochemical processes associated with the pathophysiology of autism

Such functions include transport of long-chain fatty acids from the cytoplasm to the mitochondrial matrix, regulation of acetyl-CoA/CoA, control of inter-organellar acyl traffic, and protection against oxidative stress

Furthermore, GSEA of all DEGs confirmed enrichment of pathways involving these 16 genes, including adaptive immune system terms, with directionality consistent with the primary pre/post-treatment comparison (Supplementary Fig