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Available inducers (e.g., erastin, RSL3, elesclomol) often suffer from poor pharmacokinetics, limited tumor selectivity, and narrow therapeutic windows, leading to potential off-target toxicity

This suggests that a proper balance is needed amino acid sufficiency keeps GCN2 activity in a beneficial range that supports osteoblast precursor proliferation via ATF4-driven nutrient uptake, whereas an insufficiency would over-activate GCN2s stress response and stall cell cycling [141]

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Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia

Abbreviations CA cornu ammonis CAT catalase DG dentate gyrus GSH glutathione LTP long-term potentiation mHtt mutant Huntington protein Nrf2 nuclear factor erythroid 2related factor PD Parkinson disease PFC prefrontal cortex RNS reactive nitrogen species ROS reactive oxygen species SOD superoxide dismutase Authorship Contributions Wrote or contributed to the writing of the manuscript: Salim