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After incubation for 12 h, a new peak at 3.26 ppm appeared corresponding to the -CH 2 protons of GSSG (Fig

Direct comparisons between caffeine and its metabolites regarding cognitive effects remain an important area for future research

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Its activity profile is best understood as systems-level: published in vitro and in vivo work has documented effects on fibroblast proliferation, collagen and growth-factor receptor expression, endothelial migration, nitric oxide system signalling, and dopamine and serotonin pathway markers