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Babula JAJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H

This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Evidence Quality Comparison# Side Effect and Safety Comparison# Dihexa Safety Considerations# The primary safety concern for Dihexa is specific to its mechanism

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Tissues were homogenized and lysed in NETN buffer (20 mM Tris-HCl (pH 8.0), 100 mM NaCl, 1 mM EDTA and 0.5% Nonidet P-40) supplemented with 50 mM -glycerophosphate, 5 mM NaF and a protease inhibitor cocktail (Roche)