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TET2 Tet methylcytosine dioxygenase 2 (TET2) is an important epigenetic checkpoint enzyme in MDSC that regulates myelopoiesis and immune function through the hydroxylation of methylcytosine [98]

NAT10, as an RNA acetyltransferase, dynamically regulates cardiac fibrosis through ac4C epigenetic modifications: It enhances Amotl1 mRNA stability and translational efficiency, promotes the binding of Amotl1 protein to YAP, and activates the Hippo/YAP signaling pathway, ultimately accelerating fibroblast proliferation and transdifferentiation

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NAD(H) is mainly involved in catabolic reactions, 5,12,13 whereas NADP(H) is primarily involved in cellular antioxidative effects and anabolic reactions as shown in Fig

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