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The results showed: miR-21, miR-34a, miR-92a, miR-126, and miR-200c are jointly increased in ME/CFS patients compared to healthy controls.[ref] MiR-21 and miR-126 regulate eNOS and endothelial function.[ref] MiR-21 is found abundantly in macrophages and plays a key role in regulating the anti-inflammatory response in macrophages.[ref] Immune response, cellular energy: A study involving 40 ME/CFS patients and 20 healthy controls found five upregulated miRNAs (miR-127-3p, miR-142-5p, miR-143-3p, miR-150-5p, and miR-448), and one downregulated (miR-140-5p)

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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates