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Materials and methods Cells and culture The cloned helper T cell line D10.G4.1 (D10), which recognizes chicken conalbumin peptide presented by I-A k (27), and the murine B lymphoma line CH12 (28) were kindly provided by Dr

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CAS is a relatively uncommon disorder (1-2 children per 1,000= 0.1-0.2%) and one of the lesser known disorders treated by Speech-Language Pathologists

It plays a crucial role in detoxification, immune function, and overall health

Together, these processes have mitochondrial iron metabolism underpinning both energy production and antioxidant capacity, thereby influencing cellular susceptibility to ferroptosis

In fact, treatment of macrophages with itaconate, a well-known anti-bacterial product which is a by-product of citrate and TCA activity, induces the inhibition of aldolase during LPS stimulation and prevents the production of IL1 demonstrating that aldolase promotes the production of IL1 (93)