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Rare Diseases and Genetic Disorders Peptide therapeutics have shown particular promise in treating rare diseases where traditional drug development may be economically challenging

Miguel-Alvarez M, Santos-Lozano A, Sanchis-Gaomar F, Fluza-Luces C, Pareja-Galeano H, Garatachea N, et al

Overdijk MB, Verploegen S, Bgels M, van Egmond M, Lammerts van Bueren JJ, Mutis T

In contrast, mitofusin 1 (MFN1), a highly conserved outer membrane GTPase, regulates mitochondrial fusion by initiating membrane tethering, docking, and merging between adjacent mitochondria

While PGC-1 agonists suppress NF-B via NADPH synthesis [198] (Fig

The involvement of mitochondrial antiviral signaling (MAVS) was detected by its clustering along the mitochondrial surface using immunofluorescence microscopy and semi-denaturing detergent agarose gel electrophoresis (SDD-AGE)