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Less inflammation, fewer senescent cells and less genomic instability provide a possible explanation for the life-extending effect of GlyNAC

A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

The peptide's primary mitogenic actions involve stimulation of the MAPK/ERK pathway, which promotes cell cycle progression, and the PI3K/Akt pathway, which enhances cell survival and prevents apoptosis

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It activates the ROS/JNK signaling pathway while inhibiting the Akt/mTOR pathway, leading to G2/M phase arrest and triggering autophagy (53)