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16 Airway defenses against oxidants include airway surface mucins that can scavenge HOCl and other oxidants, 17 however, oxidant stress markedly increases mucin gene transcription, goblet cell hyperplasia and mucin granule exocytosis

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In addition, the concept of precision medicine should be integrated to explore the potential for personalized treatment with AS-IV in different populations, to identify relevant biomarkers and to promote the development and clinical application of personalized medication strategies

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Both HRCTs at hospitalization (HRCT 0 ), when available, and HRCT 1 during follow-up were analyzed semiquantitatively as follows: ground-glass opacities (alveolar score, AS), consolidations (CONS), and reticulations (interstitial score, IS)