melanotic macule palate Pigmented Lesion on the Hard Pigmented (Purple or Brown) Lesions

However, virtually all patients acquire resistance to this therapy and experience disease relapse

That means tumor recurrence is unlikely after the treatment

The underlying dermis does not exhibit a host response

Exact preoperative diagnosis is difficult to achieve and they might mimic pathologies of surrounding organs or structures because of their atypical presentation

Partial List The Times of India and Corriere della Sera, Italy

This chromatic variability not only reflects the genetic factors that regulate melanin synthesis by melanocytes and its subsequent transfer to adjacent keratinocytes but is also influenced by external factors such as trauma, inflammation, hormonal fluctuations, exposure to certain pharmacological agents, external agents that can pigment the mucosa, and radiation, all of which can induce an increase in melanin production