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comparing the acute impact of tobacco versus e-cigarettes with equivalent nicotine content, found that within 5 min of smoking or vaping, both tobacco smokers and healthy individuals exhibited a statistically significant increase in sCD40L, sP-selectin, and platelet aggregation levels in a single-blind crossover trial (40)

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Three primary human cell samples were used in this study from patients (a male aged 44 years, a male aged 41 years, and a female aged 72 years) with post-traumatic or primary hip osteoarthritis, without any known condition that could influence the bone formation capacity