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While treatment with IGF-1, either intravenously for 5 d or subcutaneously for 9 d, increased plasma IGF-1 to the desired normophysiological level (70.9 4.1 and 91.0 11.8 ng/ml, respectively), this treatment length may have been insufficient to affect brain weight, motor skills, or water brain content (a surrogate marker of brain maturation

Melatonin (25 mg for 24 weeks) showed cognitive and mood improvements in human AD patients [52,75,76]

Figure 6 specifically highlights how natural products, exemplified by kaempferol-3-O-rutinoside, target multiple pathways and mechanisms in the treatment of MI

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Burns & Nicolas Cherbuin Health Research Institute, University of Canberra, Canberra, ACT, Australia Nasser Bagheri School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Sara Bagherieh & Amin Dehghan Department of Parasitology, Tarbiat Modares University, Tehran, Iran Saeed Bahadory Department of Parasitology, Alborz University of Medical Sciences, Karaj, Iran Saeed Bahadory University Institute of Public Health, The University of Lahore, Lahore, Pakistan Atif Amin Baig, Sajid Hameed, Asif Hanif & Ahmad Azam Malik Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India Mohan Bairwa & Abhishek Jaiswal Center for Clinical Research and Prevention, Bispebjerg University Hospital, Frederiksberg, Denmark Jennifer L

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