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We observed that sUA also activates the NLRP3 inflammasome through ion flux, specifically via potassium efflux, since the inhibition of cellular K + removal in WT macrophages also inhibited IL-1 production (Sup

Proline is also classified as an aliphatic amino acid, but the hydrocarbon side chain has cyclized with the terminal amine, creating a unique 5-membered ring, non-aromatic ring structure

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