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Future Direction and Call to Action The current evidence gap presents an opportunity for orthopaedic investigators to establish high-quality prospective registries evaluating peptide exposure in real-world musculoskeletal populations

SWISS-2DPAGE, ten years later

Mechanistically, GHRP-6 sustained cellular antioxidant defense, upregulated the prosurvival gene Bcl-2, and preserved cardiomyocyte mitochondrial integrity

Take, for example, BPC-157, the recovery peptide on the restricted list

Regulatory shifts in the US could expand access to peptides with limited clinical evidence, amplifying risks already driven by biohacking culture and grey-market supply chains In 2023, the United States (US) Food and Drug Administration (FDA) restricted the use of certain peptides by compounding pharmaciesfacilities that produce medications tailor-made to patientsowing to safety concerns