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The astrocytic glutamate transporter GLT-1/EAAT2 expression is markedly reduced (Rothstein et al., 1995)

PUFAs are among the primary targets of lipid peroxidation, and lipid synthesis-mediated production of PUFAs increases cellular sensitivity to ferroptosis ( 2 ) on the plasma membrane and mitochondrial inner membrane, respectively

8 , R53 (2006)

Furthermore, BDNF has never entered PD clinical trials, mainly due to poor blood-brain barrier penetration, a short half-life, and the risk of abnormal synaptic plasticity (e.g., epileptiform discharges) with overexpression [62, 63]

We anticipate that elucidating the intrinsic link between the Nrf2 pathway and ferroptosis will be the key to treating lung diseases, as illustrated in Fig