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Experimental validation revealed that NRN1 enhances LGI1 expression in the hippocampus through NRN1-mediated histone deacetylase 5 (HDAC5) phosphorylation by protein kinase D (Lee et al., 2021)

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This reward deficiency syndrome (RDS), coined by Blum et al in 1995, arises from an imbalance or deficiency in the DA system and results in diminished pleasure and satisfaction (Figure 2)