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Circulation 135 (5), 476489

Desiree Granados Editorial Process Our Editorial Process John DiBella is the co-founder and CEO at The Sanctuary Wellness Institute

Acknowledgment The authors thank The University of Nottingham and the School of Life Sciences (UK) for their scientific support

Discussion While it is well accepted that EtOH-associated oxidative stress is a key mediator in the pathogenesis of ALD, the molecular details governing this process remain incompletely understood

As a result, ongoing efforts aim to improve Rh2s delivery and bioavailabilitythrough methods like chemical structure modification and advanced nanoparticle formulationsto fully harness its therapeutic potential