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[8] Structural organization in eukaryotes and prokaryotes In eukaryotes , particularly in mammals, Drosophila , and Dictyostelium (a genus of amoebae), these three enzymatic activities are located on a single polypeptide chain, encoded by a gene derived from a gene fusion event that occurred at least 100 million years ago

Tamura et al., 2010)

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The lack of HrpA/HrpB TPS in the gonococcus would explain why the gonococcus remains predominantly confined within a vacuole during cellular infection, unlike the meningococcus, which is able to escape, and why the meningococcus, after reaching the cytosol, induces pyroptotic pathways during cellular infection, a phenomenon not described for the gonococcus