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Given that hepsin / mice were reported to have elevated mRNA levels of mitochondrial Cpt1b , Cpt2 , and Cox7a1 in adipose tissues compared with wild-type mice, suggesting a regulatory role for hepsin in metabolism (Li et al

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PDK4 functions by attenuating the activity of pyruvate dehydrogenase complex (PDC) through PDHA1, thereby promoting the preference for pyruvate dehydrogenation and accelerating the Warburg effect (50, 51)

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