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Nitrous Oxide-Induced Vitamin B12 Deficiency Resulting in Myelopathy

doi: 10.1111/apt.15785 110 JessTJensenBWAnderssonMVillumsenMAllinKH

10.1124/mol.107.043588 64 GrndlerT.QuednauN.StumpC.Orian-RousseauV.IshikawaH.WolburgH.et al (2013)

That constitutes a very busy molecule having several regions where binding and other biochemical changes can take place

Hypoxia inhibits PHD activity through a number of mechanisms, including substrate limitation (reviewed in 4 ), resulting in HIF stabilization, heterodimerization with HIF1/ARNT, and increased HIF transcriptional activity