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The cardiologist notes that this second LA/Ao, being higher than the first one nine months previously, indicates that the left artrium has continued to enlarge, and that the degree of enlargement now is "moderate"

Review of quantitative ultrasound: envelope statistics and backscatter coefficient imaging and contributions to diagnostic ultrasound

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Specifically, under stress conditions, JNK/p38 MAPK phosphorylates ATF2 to enhance its transcriptional activity (107), while ER stress activates ATF4 and ATF6 via the unfolded protein response (UPR) to restore proteostasis (106,108)