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Besides, reactive glial cells, members of the NVU, are likely to contribute to the permeability of the BBB observed in cerebral hypoxia through downregulation of paracellular proteins such as Claudin-5 (CLDN5), occludin, and ZO-1 (Obermeier et al., 2013)

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Some researchers report stability up to 6-8 weeks under strict sterile conditions, but the conservative recommendation is 4 weeks

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The lack of FDA approval for human use and the need for higher doses in some experimental settings underscore the importance of evaluating safety and efficacy under strict medical supervision