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Patients were reviewed at least every 6 months over the first 36 months of the trial to assess for the development of LRE including liver related death, hepatocellular carcinoma, large varices requiring therapy, ascites, spontaneous bacterial peritonitis and encephalopathy

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Medications that interfere with folate metabolism, such as sulfadiazine or pyrimethamine used in EPM treatment, can also reduce availability, making supplementation beneficial in some cases

Women experiencing similar symptoms can explore hormone replacement therapy, and many TRT patients also complement treatment with IV vitamin therapy for added energy and recovery support

S.NaS.KuanC.YangD.KarasuyamaH.et al (1996)