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Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

The mGold channel was divided by the SiR channel in a pixel-by-pixel manner, and the mean of all pixels in the FOV, excluding the edges, was calculated

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Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors

Beyond its role as a shield, it also helps "recycle" other antioxidants

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