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Our simulations reveal that heme binds laterally from the membrane space to the transmembrane region of CydDC, enabled by a highly asymmetrical inward-facing CydDC conformation

Activated Piezo1 also recruits the small GTPase R-RAS to the endoplasmic reticulum, leading to the release of internally stored calcium

seeing sounds) patient may be confused or disoriented, have distorted perceptions & impaired judgment mydriasis, tachycardia, mild hypertension & tachypnea, tremor patients may present themselves to the Emergency Department after having had a bad trip (uncomfortable hallucination) flashbacks occur in most patients who have taken LSD more than 10 times intoxication usually lasts 8-12 hours, but psychotic behavior may persist for days Treatment: primarily supportive care (talking down the patient) & benzodiazepines (diazepam) to decrease agitation haloperidol for acute psychosis References: Olson KR (2007): Poisoning & Drug Overdose

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