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Hothorn, T., Bretz, F

Similarly, honokiol can significantly improve DAI, colon length, and histopathological scores in vivo , and reduce inflammatory mediators while enhancing TJ proteins in vitro [487]

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Reciprocally, mast cell-derived mediators activate intestinal neurons, inducing neuronal hyperexcitability (5456), potentially precipitating neurodegeneration, neuroinflammation, and ultimately neuronal cell death

doi: 10.1146/annurev.Pharmtox.45.120403.095857

But the complexity and the chronicity of what we see is often related to this interplay