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Validation: MPB, DAP, JDDK, YR, HVW, DAF, PDK

Retatrutide's Phase 2a in MASH/MASLD (Sanyal et al., Nat Med 2024) reported approximately 86% relative reduction in liver fat content at 12 mg/week the strongest hepatic-fat data among the incretin class

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Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations

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Pharmacokinetics, safety, and tolerability of oral semaglutide in subjects with hepatic impairment