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Given that NMN itself is a non-cell penetrating biosynthetic intermediates, NMN or its metabolites may be actively transported across the membrane

Further, in response to commenters' suggestions that we complete actions quickly or timely and provide detailed responses to ACOs, we note that there are interactions between our investigation into the issues potentially impacting ACO financial calculations that may warrant reopening, and the extent to which we can provide additional information to ACOs to explain the status of our investigation and findings, and relatedly the timeline for communicating our decision or related information to the ACO that submitted the request