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*Comparison based on published research and clinical experience

Free Radic Biol Med 52(9):19541969

Fibroblastic foci Discrete aggregates of proliferating fibroblasts and myofibroblasts located beneath the alveolar epithelium, representing sites of active extracellular matrix deposition at the leading edge of active fibrosis

Notably, many polyphenols also exhibit circadian activity e.g., resveratrol can activate the SIRT1 pathway which influences the clock, and quercetin can modulate clock gene expression in cells