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We advocate that future AD research must establish a comprehensive framework that integrates iron metabolism, oxidative stress, and A/tau pathology to transcend the limitations of the traditional amyloid-centric hypothesis, thereby achieving a more holistic understanding of AD pathogenesis

These results suggest that at low doses of acetone or endogenous acetone, the methylglyoxal and lactate pathways predominate, but at higher doses, these pathways become saturated and metabolism is shunted to the formate-acetate branch of the 1,2-propanediol pathway

Folate losses reached values of 76.479.7% in glass-bottled tomato juice after storage in the dark for twelve months, irrespective of storage temperature (8, 22, and 37 C) 486

Subcutaneously administered cebranopadol reduced cold allodynia in oxaliplatin-treated mice, and this effect was observed both in the acute and the late phase of CIPN [153]

Phosphorylation of Atg5 by the Gadd45beta-MEKK4-p38 pathway inhibits autophagy

Future research should focus on exploring the use of combination therapy in cancer treatment