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However, our recent characterizations of FL-associated mutations in ATP6V1B2/VMA2 , VMA21 , and ATP6AP1 / BIG1 , in human cell lines and a yeast model, reveal that basal autophagy flux is enhanced in nutrient-replete medium even though the lysosome/vacuole is indeed deacidified 14,18,19

Arner P, Bernard S, Appelsved L, Fu KY, Andersson DP, Salehpour M, Thorell A, Rydn M, Spalding KL

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Through its modulation of the NNMT-SAM-NAD+ axis, it enhances energy expenditure and supports more efficient utilization of fat stores for energy, making it a strong candidate in studies exploring metabolic optimization and obesity control