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In addition to de novo lipid synthesis, the loss of G6PD function also led to impaired NOS2 activity in Ms activated by LPS (61) or by IFN- and infected by Trypanosoma cruzi (62)

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Additionally, we observed increased lipid peroxidation in the vicinity of the plaque

10.1016/S0753-3322(03)00043-X

These findings underscore the unique pathological timeline and molecular changes in the TgAPParc model, providing a valuable tool for studying Alzheimers disease pathogenesis and therapeutic development